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The FDA accredited the immune checkpoint inhibitors pembrolizumab and nivolumab for therapy of recurrent or metastatic HNSCC and pembrolizumab as main treatment for unresectable disease. Remedy is generally multimodal, consisting of surgical procedure adopted by chemoradiotherapy (CRT) for oral cavity cancers and first CRT for pharynx and larynx cancers. Conventional staging of HNSCC using the tumour–node–metastasis system has been supplemented by the 2017 AJCC/UICC staging system, which contains further data related to HPV-positive disease. An Writer Correction to this text was revealed on 19 January 2023
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